Xeldrin 20 mg

Description

Indications:

• Gastric and duodenal ulcers, including NSAID-associated ulcers.
• Prophylaxis for patients with a history of NSAID-associated ulcers.
• Gastro-esophageal reflux disease (GERD) and acid-related dyspepsia.
• Long-term management of acid reflux disease and severe ulcerating reflux esophagitis.
• Prophylaxis of acid aspiration during surgery and Zollinger-Ellison syndrome.
• Helicobacter pylori-induced peptic ulcer treatment (in combination with antibiotics).

Pharmacology:

• Omeprazole works by inhibiting the H+/K+ ATPase enzyme in the stomach, reducing acid secretion.
• The effects are noticeable within 1 hour, with maximum effect in 2 hours, lasting up to 72 hours.

Dosage:

• Oral:
  • For gastric and duodenal ulcers: 20 mg daily (4-8 weeks).
  • For NSAID-associated ulcers: 20 mg daily for 4 weeks.
  • GERD: 20 mg daily for 4-8 weeks.
  • For acid reflux management and other indications, doses range from 10 mg to 40 mg, based on severity.
• IV Injection:
  • Used for prophylaxis of acid aspiration and for severe cases where oral medication is inappropriate. Administered in doses of 40 mg to 60 mg, depending on the condition.

Side Effects:

• Common: Rash, urticaria, diarrhea, headache.
• Serious: Liver enzyme changes, mental confusion, photosensitivity, and rare cases of anaphylaxis or hepatic failure.

Precautions & Warnings:

• Avoid use with clopidogrel, as it reduces the drug’s efficacy.
• Long-term use may be associated with osteoporosis-related fractures and gastric atrophy.
• Caution in patients with liver disease.

Pregnancy & Lactation:

• Generally considered safe during pregnancy, but breastfeeding should be avoided unless necessary.

Storage Conditions:

• Keep in a dry place, away from heat and light, and out of reach of children.