Xelpid 10 mg

Description

Indications:
Xelpid 10 mg Tablet is prescribed as an adjunct to a proper diet for managing elevated cholesterol levels, including total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B), and triglycerides. It is recommended for patients who have not responded adequately to diet and other non-pharmacological treatments.

• Familial Hypercholesterolemia: Reduces total cholesterol and LDL cholesterol levels in patients with both heterozygous and homozygous familial hypercholesterolemia.
• Mixed Dyslipidemia (Fredrickson Type Ia and Ib): Lowers elevated cholesterol and triglycerides.
• Hypertriglyceridemia (Fredrickson Type IV): Treats patients with elevated serum triglyceride levels.
• Dysbetalipoproteinaemia (Fredrickson Type III): For managing this condition.
• Cardiac Ischaemic Events: Helps reduce cardiac events in patients with coronary artery disease and elevated LDL-cholesterol levels.
• Hypercholesterolemia in Diabetes and Renal Transplantation: Reduces total and LDL-cholesterol levels in patients with hypercholesterolemia associated with diabetes or renal transplantation.

Pharmacology:
Atorvastatin, the active ingredient in Xelpid, inhibits HMG-CoA reductase, the enzyme responsible for converting HMG-CoA to mevalonate, a precursor to cholesterol. By lowering cholesterol and lipoprotein levels in the liver, it increases hepatic LDL receptors for more effective cholesterol breakdown.

• Absorption: Xelpid is rapidly absorbed, reaching peak plasma concentrations within 1-2 hours.
• Metabolism: It is extensively metabolized in the liver and excreted primarily through bile.
• Excretion: The elimination half-life of atorvastatin is about 14 hours, while its inhibitory effects last 20-30 hours.

Dosage & Administration:

• Primary Hypercholesterolemia & Combined Hyperlipidemia: Starting dose for adults is 10 mg daily, increasing as needed to a maximum of 80 mg. For children (10-18 years), the usual starting dose is 10 mg daily, with a maximum of 20 mg daily.
• Familial Hypercholesterolemia: Initial dose for adults is 10 mg, increasing up to 80 mg daily. Children should start at 10 mg, with a maximum of 80 mg.
• Prevention of Cardiovascular Events: Starting dose is 10 mg daily, adjusted according to patient response.
• Special Populations: Dosage adjustments may be needed for elderly patients or those with liver dysfunction. Regular monitoring of liver function is recommended.

Contraindications:
Xelpid is contraindicated in patients with hypersensitivity to atorvastatin, active liver disease, or unexplained persistent elevations of serum transaminases. It should not be used in patients who have experienced serious adverse reactions to other statins.

Side Effects:
Common side effects include constipation, dyspepsia, flatulence, and abdominal pain. Less frequent effects include headache, muscle pain, rash, and fatigue. Consult your healthcare provider if you experience any unusual symptoms.

Pregnancy & Lactation:

• Pregnancy: Xelpid is contraindicated during pregnancy.
• Lactation: Not recommended during breastfeeding due to the potential excretion of atorvastatin in breast milk.

Precautions & Warnings:

• Liver function: Monitor liver function before and during treatment.
• Muscle-related issues: Discontinue treatment if myopathy is suspected.
• Diabetes: May increase blood sugar levels, so regular monitoring is essential for diabetic patients.

Storage Conditions:
Store in a dry place, away from heat and direct light. Keep out of reach of children.

FAQs:

• What is Xelpid 10 mg Tablet?
  Xelpid 10 mg is a statin medication used to lower cholesterol and triglyceride levels in patients with various lipid disorders.
• How should I take Xelpid?
  Take one tablet daily, with or without food, as prescribed by your doctor.
• What are the side effects?
  Possible side effects include muscle pain, abdominal discomfort, and digestive issues. Consult your doctor if these persist.
• Can I take Xelpid if I’m pregnant?
  No, Xelpid should not be used during pregnancy.

For more information, consult your healthcare provider.