Cerox CV (125 mg+31.25 mg)/5 ml

Description

Indications

Cerox CV is prescribed for the treatment of infections caused by susceptible bacteria, including:

• Pharyngitis/Tonsillitis – Caused by Streptococcus pyogenes
• Acute Bacterial Otitis Media – Caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes
• Acute Bacterial Sinusitis
• Bronchitis & Pneumonia – Including acute exacerbation of chronic bronchitis and community-acquired pneumonia
• Skin and Soft Tissue Infections
• Urinary Tract Infections
• Gonorrhea – Uncomplicated cases
• Typhoid Fever – Including multi-drug resistant (MDR) strains
• Early Lyme Disease

Pharmacology

Cerox CV contains a combination of Cefuroxime and Clavulanic Acid:

• Cefuroxime is a second-generation cephalosporin antibiotic with bactericidal action. It effectively targets Gram-positive and Gram-negative bacteria, including beta-lactamase-producing strains, by inhibiting bacterial cell wall synthesis.
• Clavulanic Acid is a beta-lactamase inhibitor derived from Streptomyces clavuligerus. It prevents the degradation of Cefuroxime by beta-lactamase enzymes, enhancing its effectiveness against resistant bacterial infections.

Dosage & Administration

For Adolescents & Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days
• Acute Bacterial Sinusitis: 250 mg twice daily for 10 days
• Acute Bronchitis (Bacterial Exacerbation): 250-500 mg twice daily for 10 days
• Skin & Soft Tissue Infections: 250-500 mg twice daily for 10 days
• Urinary Tract Infections: 250 mg twice daily for 7-10 days
• Uncomplicated Gonorrhea: 1000 mg as a single dose
• Community-Acquired Pneumonia: 250-500 mg twice daily for 5-10 days
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days
• Early Lyme Disease: 500 mg twice daily for 20 days

For Pediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in divided doses for 5-10 days
• Acute Otitis Media & Sinusitis: 30 mg/kg/day in divided doses for 10 days
• Impetigo: 30 mg/kg/day in divided doses for 10 days

Administration: The tablet form may be taken with or without food.

Drug Interactions

• Probenecid increases the serum concentration of Cefuroxime-Clavulanic Acid by approximately 50%.
• Gastric acid-reducing agents may lower Cefuroxime’s bioavailability and reduce absorption effectiveness.

Contraindications

• Hypersensitivity to cephalosporins
• Patients with a history of pseudomembranous colitis

Side Effects

Cerox CV is generally well tolerated, but possible side effects include:

• Common: Nausea, vomiting, diarrhea, abdominal discomfort
• Rare: Renal dysfunction, anaphylaxis, angioedema, skin rash, pruritus, serum sickness-like urticaria

Use in Pregnancy & Lactation

• Should be avoided in the first trimester unless necessary.
• Can be safely used later in pregnancy for treating infections.
• Excreted in small amounts into breast milk—use with caution.

Precautions & Warnings

• Use with caution in patients on potent diuretics.
• History of colitis should be considered before prescribing.

Storage Conditions

• Store below 30°C in a cool, dry place away from light and moisture.
• Keep out of the reach of children.

Frequently Asked Questions (FAQs)

1. What is Cerox CV 125 Suspension used for? Cerox CV 125 Suspension is used to treat bacterial infections such as tonsillitis, sinusitis, bronchitis, pneumonia, urinary tract infections, skin infections, gonorrhea, and typhoid fever.

2. How quickly does Cerox CV 125 Suspension start working? It starts acting within 2-3 hours after administration.

3. How long does the effect last? The effects typically last between 4-8 hours.

4. Can I consume alcohol while taking this medication? The interaction between Cerox CV and alcohol is unclear. It is advisable to consult a doctor before consuming alcohol.

5. Is Cerox CV 125 Suspension habit-forming? No, this medication does not cause dependency or habit formation.

6. Can this medicine be used during pregnancy? Yes, it can be safely used in pregnancy if prescribed by a doctor.

7. Is it safe to use while breastfeeding? Yes, Cerox CV 125 Suspension is generally safe for use during breastfeeding, though it enters breast milk in small amounts.

Quick Tips

• Complete the full course of the antibiotic even if symptoms improve.
• Take with food to reduce stomach upset.
• If diarrhea occurs, probiotics may help. Seek medical advice if you notice bloody stools or severe cramps.
• Stop taking the medication and contact a doctor if you experience allergic reactions such as rash, swelling, or breathing difficulties.
• Do not reuse leftover medication for future infections—always consult a doctor before taking antibiotics.

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